ambulance bed bolt briefcase calendar chain chevron-left chevron-right clock-o commenting-o commenting comments diamond envelope-o envelope facebook feed flask globe group heart-o heart heartbeat hospital-o instagram leaf map-marker medkit phone quote-left quote-right skype star-o star tint trophy twitter user-md user youtube

How do multiple memory systems give rise to behavior?

When Mar 29 2017 12:00 EDT
Where Mellon Institute Conference Room
Who Catherine Thorn, Ph.D

Postdoctoral Fellow Neuroscience and Pain Research Unit, Pfizer

Abstract: My research aims to understand how synaptic level changes in basal ganglia and hippocampal circuits underlie memory encoding and behavioral learning, and how these processes break down in neurodegenerative and neurological diseases. This talk will highlight findings from in vivo electrophysiology studies that demonstrate the coordinated activation of sensorimotor and associative striatal circuits as well as hippocampus as rats learn and perform a T-maze task. These studies have led to the development of a working model of behavioral control in which both population firing dynamics and precise spike timing are differentially modulated in sensorimotor versus associative striatal networks as behavior shifts from flexible to highly stereotyped performance across learning. Taking a closer look at the synaptic mechanisms that operate in the hippocampus during learning, I will also present recent work that examines specific actions of acetylcholine in modulating hippocampal synapses