About the presenter:
Department of Biological Sciences Carnegie Mellon University
Abstract: The mammalian brain contains a vast diversity of GABAergic inhibitory interneurons. The identification of cell type-selective molecular markers has fostered tremendous insight into how distinct cortical interneurons shape sensory processing and behavior. In the olfactory bulb, inhibitory circuits precisely regulate the activity of principal neurons to drive olfactory-guided behavior. In contrast to cortical circuits, however, selective markers for distinct olfactory bulb interneurons remain largely unknown. This gap in knowledge has greatly limited cell type-selective study of interneuron function and mechanistic understanding of sensory processing in the olfactory bulb. In this talk, I will describe our recent molecular identification of a novel class of GABAergic interneurons in the olfactory bulb. Using transgenic mice together with immunohistochemistry, acute slice electrophysiology, and optogenetic circuit mapping, we demonstrate that these interneurons integrate broadly tuned sensory input with centrifugal cholinergic input and mediate highly divergent synaptic output to dynamically regulate the balance of sensory-evoked activity between distinct classes of principal neurons.